Antiobesity action of ɛ-polylysine, a potent inhibitor of pancreatic lipase

In vitro, ɛ-polylysine (EPL) strongly inhibited the hydrolysis of trioleoylglycerol emulsified with phosphatidylcholine (PC) and taurocholate by either pancreatic lipase or carboxylester lipase. The EPL concentration required for 50% inhibition of pancreatic lipase, 0.12 μM, was eight times lower th...

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Bibliographic Details
Main Authors: Takahiro Tsujita, Hiroe Takaichi, Takeshi Takaku, Shigeyuki Aoyama, Jun Hiraki
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331709