Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation.

Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation.

INTRODUCTION: Treatment of acute lung injury (ALI) remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI also on neutrophil effector funct...

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Main Authors: Jochen Grommes, Santosh Vijayan, Maik Drechsler, Helene Hartwig, Matthias Mörgelin, Rolf Dembinski, Michael Jacobs, Thomas Andreas Koeppel, Marcel Binnebösel, Christian Weber, Oliver Soehnlein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3372465?pdf=render

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http://europepmc.org/articles/PMC3372465?pdf=render

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