SSC-ILD mouse model induced by osmotic minipump delivered bleomycin: effect of Nintedanib

Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by an excessive production and accumulation of collagen in the skin and internal organs often associated with interstitial lung disease (ILD). Its pathogenetic mechanisms are unknown and the lack of animal models mimicking the...

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Bibliographic Details
Main Authors: Francesca Ravanetti, Erica Ferrini, Luisa Ragionieri, Zahra Khalajzeyqami, Maria Nicastro, Yanto Ridwan, Alex Kleinjan, Gino Villetti, Andrea Grandi, Franco Fabio Stellari
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97728-z