Aloe-emodin Attenuates Staphylococcus aureus Pathogenicity by Interfering With the Oligomerization of α-Toxin

Aloe-emodin Attenuates Staphylococcus aureus Pathogenicity by Interfering With the Oligomerization of α-Toxin

α-toxin, an essential virulence factor secreted by Staphylococcus aureus (S. aureus), is a critical exotoxin in multiple infections. In this study, we found that aloe-emodin (AE), a natural compound lacking anti-S. aureus activity, could inhibit the hemolytic activity of α-toxin. Oligomerization ass...

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Bibliographic Details
Main Authors: Lanxiang Jiang, Tian Yi, Ziying Shen, Zihao Teng, Jianfeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Staphylococcus aureus
α-toxin
aloe-emodin
antibiotic-resistant
pneumonia
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00157/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00157/full

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