Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers.

Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers.

BACKGROUND:Positron emission tomography (PET) imaging of macrophages using the translocator protein (TSPO) tracer (R)-[11C]PK11195 has shown the promise to image rheumatoid arthritis (RA). To further improve TSPO PET for RA imaging, second generation TSPO tracers [11C]DPA-713 and [18F]DPA-714 have r...

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Bibliographic Details
Main Authors: S T G Bruijnen, N J F Verweij, Y Y J Gent, M C Huisman, A D Windhorst, M Kassiou, P M van de Ven, A A Lammertsma, O S Hoekstra, A E Voskuyl, C J van der Laken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222844

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https://doi.org/10.1371/journal.pone.0222844

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