Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells

Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells

The objectives of this study were to determine the effect of tumor necrosis factor alpha (TNF-α) on intestinal epithelial cell permeability and the expression of tight junction proteins. Caco-2 cells were plated onto Transwell® microporous filters and treated with TNF-α (10 or 100...

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Bibliographic Details
Main Authors: W. Cui, L.X. Li, C.M. Sun, Y. Wen, Y. Zhou, Y.L. Dong, P. Liu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-04-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
TNF-α
Intestinal epithelial barrier
Occludin
Caco-2 cells
Transepithelial permeability
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400002

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400002

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