Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice

Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice

The arcuate nucleus of the hypothalamus is a key regulator of energy balance and glucose homeostasis. In particular, arcuate proopiomelanocortin (POMC) neurons inhibit food intake, stimulate energy expenditure and increase glucose tolerance. The interruption of insulin or glucose signaling in POMC n...

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Bibliographic Details
Main Authors: Ramiro Alsina, Milagros Trotta, Viviana Florencia Bumaschny
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Endocrinology
Subjects:
proopiomelanocortin
glucose tolerance
insulin sensitivity
diabetes
hypothalamus
Esr1
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00554/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00554/full

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