The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

Summary: TBK1 is an essential kinase for the innate immune response against viral infection. However, the key molecular mechanisms regulating the TBK1 activation remain elusive. Here, we identify PRMT1, a type I protein arginine methyltransferase, as an essential regulator of TBK1 activation. PRMT1...

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Bibliographic Details
Main Authors: Zhenzhen Yan, Haifeng Wu, Hansen Liu, Guimin Zhao, Honghai Zhang, Wanxin Zhuang, Feng Liu, Yi Zheng, Bingyu Liu, Lei Zhang, Chengjiang Gao
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
protein arginine methylation
innate antiviral immunity
PRMT1
TBK1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011803

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http://www.sciencedirect.com/science/article/pii/S2211124721011803

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