Enhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study

Enhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study

This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD) was employed to optimize the formulation vari...

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Bibliographic Details
Main Authors: Ahmed R. Fares, Aliaa N. ElMeshad, Mohamed A. A. Kassem
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
lacidipine
central composite design
pluronics
polymeric micelles
dissolution rate
bioavailability study
Online Access:http://dx.doi.org/10.1080/10717544.2017.1419512

Internet

http://dx.doi.org/10.1080/10717544.2017.1419512

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