Hepatocyte Growth Factor Suppresses Transforming Growth Factor-Beta-1 and Type III Collagen in Human Primary Renal Fibroblasts

Hepatocyte Growth Factor Suppresses Transforming Growth Factor-Beta-1 and Type III Collagen in Human Primary Renal Fibroblasts

Tubulointerstitial changes in the diabetic kidney correlate closely with renal fibrosis, and transforming growth factor-beta-1 (TGF-β1) is thought to play a key role in this process. In contrast, hepatocyte growth factor (HGF) has shown therapeutic effects on injured renal tubules in animal models....

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Bibliographic Details
Main Authors: Shan Mou, Qin Wang, Beili Shi, Leyi Gu, Zhaohui Ni
Format: Article
Language:English
Published: Wiley 2009-11-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
c-Met
diabetic nephropathy
hepatocyte growth factor
interstitial fibrosis
transforming growth factor-β1
Online Access:http://www.sciencedirect.com/science/article/pii/S1607551X09705601

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http://www.sciencedirect.com/science/article/pii/S1607551X09705601

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