Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells

Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells

Platinum‐based compounds remain a well‐established chemotherapy for cancer treatment despite their adverse effects which substantially restrict the therapeutic windows of the drugs. Both the cell type‐specific toxicity and the clinical responsiveness of tumors have been associated with mechanisms th...

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Bibliographic Details
Main Authors: Margarita Melnikova, Ulrike Sophie Wauer, Diana Mendus, Ralf Axel Hilger, Trudy G. Oliver, Kim Mercer, Björn Oliver Gohlke, Kati Erdmann, Dieter Niederacher, Hans Neubauer, Paul Buderath, Pauline Wimberger, Jan Dominik Kuhlmann, Jürgen Thomale
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Molecular Oncology
Subjects:
cisplatin
drug import/export
platinum DNA adducts
MRP transporter family
ovarian cancer
oto-/ nephro-/ neurotoxicity
Online Access:https://doi.org/10.1002/1878-0261.12648

Internet

https://doi.org/10.1002/1878-0261.12648

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