Haplotype-aware diplotyping from noisy long reads

Haplotype-aware diplotyping from noisy long reads

Abstract Current genotyping approaches for single-nucleotide variations rely on short, accurate reads from second-generation sequencing devices. Presently, third-generation sequencing platforms are rapidly becoming more widespread, yet approaches for leveraging their long but error-prone reads for g...

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Bibliographic Details
Main Authors: Jana Ebler, Marina Haukness, Trevor Pesout, Tobias Marschall, Benedict Paten
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Genome Biology
Subjects:
Computational genomics
Long reads
Genotyping
Phasing
Haplotypes
Diplotypes
Online Access:http://link.springer.com/article/10.1186/s13059-019-1709-0

Internet

http://link.springer.com/article/10.1186/s13059-019-1709-0

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