Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing

Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing

A complex system regulating HLA-C expression in NK cells, driven by an NK-specific promoter that produces alternatively spliced variants of the 5′-UTR has been recently identified. Exon content of the NK-specific 5′-UTR varies strikingly across HLA-C alleles, with some exons being allele specific. I...

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Bibliographic Details
Main Authors: Frederick J. Goodson-Gregg, Brian Rothbard, Amy Zhang, Paul W. Wright, Hongchuan Li, Victoria E. Walker-Sperling, Mary Carrington, Stephen K. Anderson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
human
HLA-C
NK
alternative splicing
NK-promoter
peptide loading
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03034/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03034/full

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