Loss of β-Cytoplasmic Actin in the Intestinal Epithelium Increases Gut Barrier Permeability in vivo and Exaggerates the Severity of Experimental Colitis

Loss of β-Cytoplasmic Actin in the Intestinal Epithelium Increases Gut Barrier Permeability in vivo and Exaggerates the Severity of Experimental Colitis

Intestinal epithelial barrier is critical for the maintenance of normal gut homeostasis and disruption of this barrier may trigger or exaggerate mucosal inflammation. The actin cytoskeleton is a key regulator of barrier structure and function, controlling the assembly and permeability of epithelial...

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Bibliographic Details
Main Authors: Susana Lechuga, Nayden G. Naydenov, Alex Feygin, Michael Cruise, James M. Ervasti, Andrei I. Ivanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
actin isoforms
cytoskeleton
barrier
tight junctions
adherens junctions
mucosal inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.588836/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.588836/full

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