Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane.

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane.

Seipin is a disk-like oligomeric endoplasmic reticulum (ER) protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can trap TAGs in the ER bilayer via the luminal hydropho...

Full description

Bibliographic Details
Main Authors: Xavier Prasanna, Veijo T Salo, Shiqian Li, Katharina Ven, Helena Vihinen, Eija Jokitalo, Ilpo Vattulainen, Elina Ikonen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000998

Internet

https://doi.org/10.1371/journal.pbio.3000998

Similar Items