[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.

[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.

Evidence indicates that synchronization of cortical activity at gamma-band frequencies, mediated through GABA-A receptors, is important for perceptual/cognitive processes. To study GABA signaling in vivo, we recently used a novel positron emission tomography (PET) paradigm measuring the change in bi...

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Bibliographic Details
Main Authors: W Gordon Frankle, Raymond Y Cho, N Scott Mason, Chi-Min Chen, Michael Himes, Christopher Walker, David A Lewis, Chester A Mathis, Rajesh Narendran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3288104?pdf=render

Internet

http://europepmc.org/articles/PMC3288104?pdf=render

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