A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation

A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation

BackgroundThe anti-inflammatory effect of an α7nAChR agonist, PNU-282987, has previously been explored in the context of inflammatory disease. However, the effects of PNU-282987 on type 2 innate lymphoid cells (ILC2s)-mediated allergic airway inflammation has not yet been established.AimsTo determin...

Full description

Bibliographic Details
Main Authors: Fang Yuan, Lili Jiang, Qianyang Li, Leon Sokulsky, Yuanyuan Wanyan, Lingli Wang, Xiaojie Liu, Lujia Zhou, Hock L. Tay, Guojun Zhang, Ming Yang, Fuguang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
type 2 innate lymphoid cells
airway
inflammation
nicotinic acetylcholine receptor
Alternaria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.598165/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.598165/full

Similar Items