Endothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system.

Endothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system.

TGFβ signalling in endothelial cells is important for angiogenesis in early embryonic development, but little is known about its role in early postnatal life. To address this we used a tamoxifen inducible Cre-LoxP strategy in neonatal mice to deplete the TypeII TGFβ receptor (Tgfbr2) specifically in...

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Bibliographic Details
Main Authors: Kathleen R Allinson, Hye Shin Lee, Marcus Fruttiger, Joseph H McCarty, Helen M Arthur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3383742?pdf=render

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http://europepmc.org/articles/PMC3383742?pdf=render

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