Hydrogen Sulfide Protects Against Ammonia-Induced Neurotoxicity Through Activation of Nrf2/ARE Signaling in Astrocytic Model of Hepatic Encephalopathy

Hydrogen Sulfide Protects Against Ammonia-Induced Neurotoxicity Through Activation of Nrf2/ARE Signaling in Astrocytic Model of Hepatic Encephalopathy

Objective: Hepatic encephalopathy (HE) characterized by neuropsychiatric abnormalities is a major complication of cirrhosis with high mortality. However, the pathogenesis of HE has not been fully elucidated. This study aimed to determine endogenous hydrogen sulfide (H2S) in the blood of HE patients...

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Bibliographic Details
Main Authors: Xiaozhi Jin, Dazhi Chen, Faling Wu, Lei Zhang, Yu Huang, Zhuo Lin, Xiaodong Wang, Rui Wang, Lanman Xu, Yongping Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hepatic encephalopathy
primary astrocytes
H2S
blood microbiota
Nrf2
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.573422/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.573422/full

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