In silico and in vitro identification of secoisolariciresinol as a re-sensitizer of P-glycoprotein-dependent doxorubicin-resistance NCI/ADR-RES cancer cells

In silico and in vitro identification of secoisolariciresinol as a re-sensitizer of P-glycoprotein-dependent doxorubicin-resistance NCI/ADR-RES cancer cells

P-glycoprotein (P-gp) is one of the highly expressed cancer cell efflux transporters that cause the failure of chemotherapy. To reverse P-gp induced multidrug resistance, we employed a flaxseed-derived lignan; secoisolariciresinol (SECO) that acts as an inhibitor of breast cancer resistance protein;...

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Bibliographic Details
Main Authors: Mohamed A. Morsy, Azza A.K. El-Sheikh, Ahmed R.N. Ibrahim, Katharigatta N. Venugopala, Mahmoud Kandeel
Format: Article
Language:English
Published: PeerJ Inc. 2020-06-01
Series:PeerJ
Subjects:
Doxorubicin
Molecular dynamics
P-glycoprotein
Secoisolariciresinol
Rhodamine assay
MTT assay
Online Access:https://peerj.com/articles/9163.pdf

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https://peerj.com/articles/9163.pdf

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