Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

Abstract Background Niemann-Pick disease type C (NPC) is a progressive neurodegenerative condition that results in early fatality. NPC is inherited in an autosomal recessive pattern from mutations in NPC1 or NPC2 genes. The etiology of NPC is poorly defined. In that regard, neuroinflammation occurs...

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Bibliographic Details
Main Authors: Samuel D. Shin, Alexandra Shin, Karina Mayagoitia, Lorraine Siebold, Marsilio Rubini, Christopher G. Wilson, Denise L. Bellinger, Salvador Soriano
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Niemann-Pick disease type C
Neurodegeneration
Neuroinflammation
Gene Expression
Amyloid precursor protein
Online Access:https://doi.org/10.1186/s12974-019-1663-5

Internet

https://doi.org/10.1186/s12974-019-1663-5

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