Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway

Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway

Summary: Vascular endothelium dysfunction plays a pivotal role in the initiation and progression of multiple organ dysfunction. The mesenchymal stem cell (MSC) maintains vascular endothelial barrier survival via secreting bioactive factors. However, the mechanism of human umbilical cord MSC (hMSC) i...

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Bibliographic Details
Main Authors: Lingying Liu, Huinan Yin, Xingxia Hao, Huifeng Song, Jiake Chai, Hongjie Duan, Yang Chang, Longlong Yang, Yushou Wu, Shaofang Han, Xiaoteng Wang, Xiaotong Yue, Yunfei Chi, Wei Liu, Qiong Wang, Hongyu Wang, Hailiang Bai, Xiuxiu Shi, Shaozeng Li
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Clinical Genetics
Cellular Therapy
Stem Cells Research
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030571X

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http://www.sciencedirect.com/science/article/pii/S258900422030571X

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