Silibinin Suppresses TNF-α-Induced MMP-9 Expression in Gastric Cancer Cells through Inhibition of the MAPK Pathway

Silibinin Suppresses TNF-α-Induced MMP-9 Expression in Gastric Cancer Cells through Inhibition of the MAPK Pathway

Tumor necrosis factor (TNF)-α is one of the pro-inflammatory cytokines highly expressed in Helicobacter pylori that inhibits gastric acid secretion. In this study we determined the effect of silibinin on TNF-α-induced MMP-9 expression in gastric cancer cell lines. MMP-9 mRNA and protein expression w...

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Bibliographic Details
Main Authors: Sung Kim, Jeong Eon Lee, Jung-Hyun Yang, Seok Jin Nam, Jun-Ho Choe, Jung-Han Kim, Wan Wook Kim, Sung Mo Hur, Sung Hoon Kim, Se Kyung Lee, Min Gew Choi, Hye Sook Lee, Jee Soo Kim, Sangmin Kim
Format: Article
Language:English
Published: MDPI AG 2009-10-01
Series:Molecules
Subjects:
silibinin
TNF-α
MMP-9
gastric cancer
Online Access:http://www.mdpi.com/1420-3049/14/11/4300/

Internet

http://www.mdpi.com/1420-3049/14/11/4300/

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