Modeling and Bioinformatics Identify Responders to G-CSF in Patients With Amyotrophic Lateral Sclerosis

Modeling and Bioinformatics Identify Responders to G-CSF in Patients With Amyotrophic Lateral Sclerosis

Objective: Developing an integrative approach to early treatment response classification using survival modeling and bioinformatics with various biomarkers for early assessment of filgrastim (granulocyte colony stimulating factor) treatment effects in amyotrophic lateral sclerosis (ALS) patients. Fi...

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Bibliographic Details
Main Authors: Siw Johannesen, J. Russell Huie, Bettina Budeus, Sebastian Peters, Anna M. Wirth, Sabine Iberl, Tina Kammermaier, Ines Kobor, Eva Wirkert, Sabrina Küspert, Marlene Tahedl, Jochen Grassinger, Tobias Pukrop, Armin Schneider, Ludwig Aigner, Wilhelm Schulte-Mattler, Gerhard Schuierer, Winfried Koch, Tim-Henrik Bruun, Adam R. Ferguson, Ulrich Bogdahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neurology
Subjects:
amyotrophic lateral sclerosis
granulocyte-colony stimulating factor (G-CSF)
filgrastim
biomarker
modeling
principal component analysis (PCA)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.616289/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.616289/full

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