Nuclear localization of Suppressor of Cytokine Signaling (SOCS)-1 regulates local immunity in the lung

Nuclear localization of Suppressor of Cytokine Signaling (SOCS)-1 regulates local immunity in the lung

Suppressor of cytokine signaling 1 (SOCS1) is a negative feedback inhibitor of cytoplasmic Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling. SOCS1 also contains a nuclear localization sequence (NLS), yet the in vivo importance of nuclear translocation is unkno...

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Bibliographic Details
Main Authors: Jana Zimmer, Michael Weitnauer, Sébastien Boutin, Günter Küblbeck, Sabrina Thiele, Patrick Walker, Felix Lasitschka, Lars Lunding, Zane Orinska, Christina Vock, Bernd Arnold, Michael Wegmann, Alexander Dalpke
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Inflammation
Lung
Signal Transduction
rodent
Transgenic mice
cytokine signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00514/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00514/full

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