Metal-induced stabilization and activation of plasmid replication initiator RepB

Initiation of plasmid rolling circle replication is catalyzed by a plasmid-encoded Rep protein that performs a Tyr- and metal-dependent site-specific cleavage of one DNA strand within the double-strand origin of replication. The crystal structure of RepB, the initiator protein of the streptococcal p...

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Bibliographic Details
Main Authors: José Ángel Ruiz-Masó, Lorena Bordanaba-Ruiseco, Marta Sanz, Margarita Menéndez, Gloria Del Solar
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00056/full