A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies

Abstract Background Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strongly selected mutations that are not associated with immune responses res...

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Bibliographic Details
Main Authors: Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, Feng Gao
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Retrovirology
Subjects:
Mutation
Selection
Immune responses
Cryptic T cell response
Fitness
Escape
Online Access:http://link.springer.com/article/10.1186/s12977-017-0371-4

Internet

http://link.springer.com/article/10.1186/s12977-017-0371-4

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