Computer prediction of biological activity of dimethyl-N-(benzoyl)amidophosphate and dimethyl-N-(phenylsulfonyl)amidophosphate, evaluation of their cytotoxic activity against leukemia cells in vitro

Computer prediction of biological activity of dimethyl-N-(benzoyl)amidophosphate and dimethyl-N-(phenylsulfonyl)amidophosphate, evaluation of their cytotoxic activity against leukemia cells in vitro

Structural analogues of β-diketones – dimethyl-N-(benzoyl)amidophosphate (HCP) and dimethyl-N-(phenylsulfonyl)amidophosphate (HSP) were synthesized and identified by the methods of IR, 1H and 31P NMR spectroscopy. Screening of biological activity and calculation of physicochemical parameters of HCP...

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Bibliographic Details
Main Authors: I. I. Grynyuk, S. V. Prylutska, N. S. Kariaka, T. Yu. Sliva, O. V. Moroz, D. V. Franskevych, V. M. Amirkhanov, O. P. Matyshevska, M. S. Slobodyanik
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2015-12-01
Series:Ukrainian Biochemical Journal
Subjects:
cytotoxicity
dimethyl-N-(benzoyl)amidophosphate
dimethyl-N-(phenylsulfonyl)amidophosphate
L1210 leukemic cells
PASS-prognosis
ROS
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Grynyuk_6_15.pdf

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http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Grynyuk_6_15.pdf

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