Autosomal dominant polycystic kidney disease and pioglitazone for its therapy: a comprehensive review with an emphasis on the molecular pathogenesis and pharmacological aspects

Autosomal dominant polycystic kidney disease and pioglitazone for its therapy: a comprehensive review with an emphasis on the molecular pathogenesis and pharmacological aspects

Abstract Autosomal dominant polycystic kidney disease (ADPKD) is an inherited chronic kidney disorder (CKD) that is characterized by the development of numerous fluid-filled cysts in kidneys. It is caused either due to the mutations in the PKD1 or PKD2 gene that encodes polycystin-1 and polycystin-2...

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Bibliographic Details
Main Authors: Aryendu Kumar Saini, Rakesh Saini, Shubham Singh
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Molecular Medicine
Subjects:
PPAR gamma
Cystic fibrosis
Polycystin-1
Hedgehog pathway
JAK2 protein
MAP kinase signaling system
Online Access:https://doi.org/10.1186/s10020-020-00246-3

Internet

https://doi.org/10.1186/s10020-020-00246-3

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