HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease

HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease

To contend with the deleterious effects of accumulating misfolded protein aggregates or damaged organelles cells rely on a system of quality control processes, among them the autophagy-lysosome pathway. This pathway is itself controlled by a master regulator transcription factor termed transcription...

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Bibliographic Details
Main Authors: Angela S. Brijmohan, Sri N. Batchu, Syamantak Majumder, Tamadher A. Alghamdi, Karina Thieme, Sarah McGaugh, Youan Liu, Suzanne L. Advani, Bridgit B. Bowskill, M. Golam Kabir, Laurette Geldenhuys, Ferhan S. Siddiqi, Andrew Advani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
chronic kidney disease
diabetic nephropathy
autophagy
endoplasmic reticulum stress
renal tubule
Tubastatin A
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00034/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00034/full

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