Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection

Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection

Abstract Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses in the brain are tightly associated with the neuropathologic hallmarks of neurodegenerative disease, but understanding...

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Bibliographic Details
Main Authors: Farina J. Mahmud, Yong Du, Elizabeth Greif, Thomas Boucher, Robert F. Dannals, William B. Mathews, Martin G. Pomper, Polina Sysa-Shah, Kelly A. Metcalf Pate, Claire Lyons, Bess Carlson, Maria Chacona, Amanda M. Brown
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
Neuroimaging
Neuroinflammation
Microglial activation
DPA-713
Purkinje cells
Human immunodeficiency virus type-1
Online Access:http://link.springer.com/article/10.1186/s12974-020-01949-4

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http://link.springer.com/article/10.1186/s12974-020-01949-4

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