Population history and natural selection shape patterns of genetic variation in 132 genes.

Identifying regions of the human genome that have been targets of natural selection will provide important insights into human evolutionary history and may facilitate the identification of complex disease genes. Although the signature that natural selection imparts on DNA sequence variation is diffi...

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Bibliographic Details
Main Authors: Joshua M Akey, Michael A Eberle, Mark J Rieder, Christopher S Carlson, Mark D Shriver, Deborah A Nickerson, Leonid Kruglyak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC515367?pdf=render