γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity.

γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity.

Peptide Nucleic Acids (PNAs), nucleic acid analogues showing high stability to enzyme degradation and strong affinity and specificity of binding toward DNA and RNA are widely investigated as tools to interfere in gene expression. Several studies have been focused on PNA analogues with modifications...

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Bibliographic Details
Main Authors: Concetta Avitabile, Loredana Moggio, Gaetano Malgieri, Domenica Capasso, Sonia Di Gaetano, Michele Saviano, Carlo Pedone, Alessandra Romanelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3346730?pdf=render

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http://europepmc.org/articles/PMC3346730?pdf=render

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