Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum.

The cholinergic class of anthelmintic drugs is used for the control of parasitic nematodes. One of this class of drugs, tribendimidine (a symmetrical diamidine derivative, of amidantel), was developed in China for use in humans in the mid-1980s. It has a broader-spectrum anthelmintic action against...

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Bibliographic Details
Main Authors: Alan P Robertson, Sreekanth Puttachary, Samuel K Buxton, Richard J Martin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4334517?pdf=render