Boc5, a non-peptidic glucagon-like Peptide-1 receptor agonist, invokes sustained glycemic control and weight loss in diabetic mice.

Boc5, a non-peptidic glucagon-like Peptide-1 receptor agonist, invokes sustained glycemic control and weight loss in diabetic mice.

BACKGROUND: Our recent discovery of the substituted cyclobutane Boc5, one of the first non-peptidic agonists at glucagon-like peptide-1 receptors, offers the potential of combining oral availability with full agonism capable of eliciting antidiabetic and antiobesity effects. The present study was ai...

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Bibliographic Details
Main Authors: Haoran Su, Min He, Hongmei Li, Qing Liu, Jia Wang, Yiqian Wang, Weiwei Gao, Ling Zhou, Jiayu Liao, Andrew A Young, Ming-Wei Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2483413?pdf=render

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http://europepmc.org/articles/PMC2483413?pdf=render

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