Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT

Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT

Obacunone, a limonin triterpenoid extracted from Phellodendronchinense Schneid or Dictamnus dasycarpusb Turcz plant, elicits a variety of pharmacological effects such as anti-inflammatory, anti-neoplastic, anti-oxidation, and anti-lung-fibrosis ones. However, the anti-fibrotic effect of obacunone an...

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Bibliographic Details
Main Authors: Yongquan Bai, Wenwen Wang, Li Wang, Lirong Ma, Dongsheng Zhai, Furong Wang, Rui Shi, Chaoyang Liu, Qing Xu, Guo Chen, Zifan Lu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
obacunone
liver fibrosis
EMT
hepatic stellate cells
GPx-4
TGF-β
Online Access:https://www.mdpi.com/1420-3049/26/2/318

Internet

https://www.mdpi.com/1420-3049/26/2/318

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