Triptolide Attenuates Transplant Vasculopathy Through Multiple Pathways

Triptolide Attenuates Transplant Vasculopathy Through Multiple Pathways

Transplant vasculopathy (TV), a hallmark of chronic allograft rejection, is the primary cause of allograft loss after organ transplantation. Because multiple mechanisms are involved in TV pathogenesis, effective therapy for it remains elusive. Here, we identify the role of triptolide, which has a wi...

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Bibliographic Details
Main Authors: Zihuan Luo, Tao Liao, Yannan Zhang, Haofeng Zheng, Qipeng Sun, Fei Han, Zhe Yang, Qiquan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
transplant vasculopathy
triptolide
IFN-γ
donor-specific antibodies
vascular smooth muscle cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00612/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00612/full

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