Discovery of Akt Kinase Inhibitors through Structure-Based Virtual Screening and Their Evaluation as Potential Anticancer Agents

Discovery of Akt Kinase Inhibitors through Structure-Based Virtual Screening and Their Evaluation as Potential Anticancer Agents

Akt acts as a pivotal regulator in the PI3K/Akt signaling pathway and represents a potential drug target for cancer therapy. To search for new inhibitors of Akt kinase, we performed a structure-based virtual screening using the DOCK 4.0 program and the X-ray crystal structure of human Akt kinase. Fr...

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Bibliographic Details
Main Authors: Chih-Hung Chuang, Ta-Chun Cheng, Yu-Ling Leu, Kuo-Hsiang Chuang, Shey-Cherng Tzou, Chien-Shu Chen
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:International Journal of Molecular Sciences
Subjects:
Akt kinase
inhibitors
cancer
virtual screening
docking
Online Access:http://www.mdpi.com/1422-0067/16/2/3202

Internet

http://www.mdpi.com/1422-0067/16/2/3202

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