Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation

Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation

New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (<b>4a</b>–<b>4o</b>), were rationally designed and synthesized. The target compounds were screened for in vitro antiproliferative efficacy in the triple-negative breast cancer (TNBC) cel...

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Bibliographic Details
Main Authors: Buthina A. Al-Oudat, Hariteja Ramapuram, Saloni Malla, Suaad A. Audat, Noor Hussein, Jenna M. Len, Shikha Kumari, Mel F. Bedi, Charles R. Ashby, Amit K. Tiwari
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
triple-negative breast cancer
cytotoxicity
chrysin analogues
flavonoid
anticancer compounds
Online Access:https://www.mdpi.com/1420-3049/25/13/3063

Internet

https://www.mdpi.com/1420-3049/25/13/3063

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