Mannosylated linear and cyclic single amino acid mutant peptides using a small 10 amino acid linker constitute promising candidates against Multiple Sclerosis

Mannosylated linear and cyclic single amino acid mutant peptides using a small 10 amino acid linker constitute promising candidates against Multiple Sclerosis

Multiple sclerosis (MS) is a serious autoimmune demyelinating disease leading to loss of neurological function. The design and synthesis of various altered peptide ligands (APLs) of immunodominant epitopes of myelin proteins to alter the autoimmune response, is a promising therapeutic approach for M...

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Bibliographic Details
Main Authors: Stephanie eDay, Theodore eTselios, Maria-Eleni eAndroutsou, Anthi eTapeinou, Irene eFrilligou, Lily eStojanovska, John eMatsoukas, Vasso eApostolopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Immunology
Subjects:
Multiple Sclerosis
mannan
Myelin Basic Protein
altered peptide ligands
MBP83-99
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00136/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00136/full

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