Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation

Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation

Patients with diabetes mellitus (DM) are at high risk for cognitive dysfunction. Endoplasmic reticulum stress (ERS) and inflammation play crucial roles in DM. Gastrodin (Gas), the main component of Gastrodia elata, possesses anti-oxidative stress, anti-inflammatory, and neuroprotective effects. This...

Full description

Bibliographic Details
Main Authors: Tianyuan Ye, Xiangbao Meng, Yadong Zhai, Weijie Xie, Ruiying Wang, Guibo Sun, Xiaobo Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
cognitive dysfunction
diabetes mellitus
NLRP3 inflammasome
endoplasmic reticulum stress
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01346/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01346/full

Similar Items