Higher interferon score and normal complement levels may identify a distinct clinical subset in children with systemic lupus erythematosus

Higher interferon score and normal complement levels may identify a distinct clinical subset in children with systemic lupus erythematosus

Abstract Background Systemic lupus erythematosus (SLE) is a complex multi-system disease, characterized by both autoimmune and autoinflammatory clinical and laboratory features. The role of type I interferon (IFN) in SLE has been demonstrated from the 2000s, by gene expression analyses showing signi...

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Bibliographic Details
Main Authors: Alessandra Tesser, Luciana Martins de Carvalho, Paula Sandrin-Garcia, Alessia Pin, Serena Pastore, Andrea Taddio, Luciana Rodrigues Roberti, Rosane Gomes de Paula Queiroz, Virginia Paes Leme Ferriani, Sergio Crovella, Alberto Tommasini
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematosus
Interferon score
Complement
Autoinflammation
Autoimmunity
Patients’ stratification
Online Access:http://link.springer.com/article/10.1186/s13075-020-02161-8

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http://link.springer.com/article/10.1186/s13075-020-02161-8

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