Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage

Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage

Abstract Background Gene expression is highly variable across tissues of multi-cellular organisms, influencing the codon usage of the tissue-specific transcriptome. Cancer disrupts the gene expression pattern of healthy tissue resulting in altered codon usage preferences. The topic of codon usage ch...

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Bibliographic Details
Main Authors: Douglas Meyer, Jacob Kames, Haim Bar, Anton A. Komar, Aikaterini Alexaki, Juan Ibla, Ryan C. Hunt, Luis V. Santana-Quintero, Anton Golikov, Michael DiCuccio, Chava Kimchi-Sarfaty
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Genome Medicine
Subjects:
CancerCoCoPUTs
The Cancer Genome Atlas (TCGA)
Cancer transcriptome
Codon usage
Codon pair
Relative synonymous codon usage (RSCU)
Online Access:https://doi.org/10.1186/s13073-021-00935-6

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https://doi.org/10.1186/s13073-021-00935-6

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