Lymph Node Stromal Cells Enhance Drug-Resistant Colon Cancer Cell Tumor Formation through SDF-1α/CXCR4 Paracrine Signaling

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths in America. Nearly two thirds of newly diagnosed CRC cases include lymph node (LN) involvement, and LN metastasis is one of the strongest negative prognostic factors for CRC. It is thou...

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Bibliographic Details
Main Authors: David A. Margolin, Jennifer Silinsky, Chelsea Grimes, Nakia Spencer, Melissa Aycock, Heather Green, Jose Cordova, Nancy K. Davis, Tiffany Driscoll, Li Li
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800394