Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family

Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family

The (S)-adenosyl-L-methionine (SAM)-dependent methyltransferases play essential roles in post-translational modifications (PTMs) and other miscellaneous biological processes, and are implicated in the pathogenesis of various genetic disorders and cancers. Increasing efforts have been committed towar...

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Bibliographic Details
Main Authors: Fei Li, Xiaozhe Wan, Jing Xing, Xiaoqin Tan, Xutong Li, Yulan Wang, Jihui Zhao, Xiaolong Wu, Xiaohong Liu, Zhaojun Li, Xiaomin Luo, Wencong Lu, Mingyue Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Chemistry
Subjects:
deep neural network
virtual screening
methyltransferase
epigenetic
drug design
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00324/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00324/full

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