Adverse physiologic effects of Western diet on right ventricular structure and function: role of lipid accumulation and metabolic therapy

Little is known about the impact of metabolic syndrome (MS) on right ventricular (RV) structure and function. We hypothesized that mice fed a Western diet (WD) would develop RV lipid accumulation and impaired RV function, which would be ameliorated with metformin. Male C57/Bl6 mice were fed a WD or...

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Bibliographic Details
Main Authors: Evan L. Brittain, Megha Talati, Niki Fortune, Vineet Agrawal, David F. Meoli, James West, Anna R. Hemnes
Format: Article
Language:English
Published: SAGE Publishing 2018-12-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894018817741