In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

Abstract Background Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeostasis, has recently emerged as an approach to red...

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Bibliographic Details
Main Authors: Alba Carreras, Luna Simona Pane, Roberto Nitsch, Katja Madeyski-Bengtson, Michelle Porritt, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Elke Ericson, Mikael Bjursell, Marta Perez-Alcazar, Frank Seeliger, Magnus Althage, Ralph Knöll, Ryan Hicks, Lorenz M. Mayr, Rosie Perkins, Daniel Lindén, Jan Borén, Mohammad Bohlooly-Y, Marcello Maresca
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Biology
Subjects:
Hypercholesterolemia
PCSK9
Genome editing
Base editing
CRISPR-Cas9
Online Access:http://link.springer.com/article/10.1186/s12915-018-0624-2

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http://link.springer.com/article/10.1186/s12915-018-0624-2

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