Evolution of resistance mechanisms and biological characteristics of rifampicin-resistant Staphylococcus aureus strains selected in vitro

Evolution of resistance mechanisms and biological characteristics of rifampicin-resistant Staphylococcus aureus strains selected in vitro

Abstract Background We aimed to determine the evolutionary pathways of rifampicin resistance in Staphylococcus aureus, and the impact of resistance mutations in the rpoB gene on fitness. Methods Three clinical strains and one reference strain were used to select for rifampicin-resistant S. aureus va...

Full description

Bibliographic Details
Main Authors: Chong Wang, Renchi Fang, Beibei Zhou, Xuebin Tian, Xiucai Zhang, Xiangkuo Zheng, Siqin Zhang, Guofeng Dong, Jianming Cao, Tieli Zhou
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Microbiology
Subjects:
Staphylococcus aureus
Rifampicin resistance
Drug resistance evolution
Fitness cost
Online Access:http://link.springer.com/article/10.1186/s12866-019-1573-9

Internet

http://link.springer.com/article/10.1186/s12866-019-1573-9

Similar Items