Chiral isothiourea-catalyzed kinetic resolution of 4-hydroxy[2.2]paracyclophane

Chiral isothiourea-catalyzed kinetic resolution of 4-hydroxy[2.2]paracyclophane

We herein report a method for the kinetic resolution of racemic 4-hydroxy[2.2]paracyclophane by means of a chiral isothiourea-catalyzed acylation with isobutyric anhydride. This protocol allows for a reasonable synthetically useful s-factor of 20 and provides a novel entry to obtain this interesting...

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Bibliographic Details
Main Authors: David Weinzierl, Mario Waser
Format: Article
Language:English
Published: Beilstein-Institut 2021-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
acylation
kinetic resolution
nucleophilic catalysis
paracyclophanes
planar chirality
Online Access:https://doi.org/10.3762/bjoc.17.68

Internet

https://doi.org/10.3762/bjoc.17.68

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