Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting

Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting

Abstract Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the possible reasons may be the protection of integrase from proteasomal degradation by Ku70 subunit. We demonstrated that recombinant HIV-1 integrase and Ku70 form a stable complex, while no interaction of Ku70 with in...

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Bibliographic Details
Main Authors: Andrey N. Anisenko, Ekaterina S. Knyazhanskaya, Artur O. Zalevsky, Julia Yu Agapkina, Aleksander I. Sizov, Timofey S. Zatsepin, Marina B. Gottikh
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05659-5

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https://doi.org/10.1038/s41598-017-05659-5

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